Nanodevices Based on Actin-Filament End-Tracking Motors

In a continuing research project, nanoscale actuators based on actin-filament end- tracking motors have been synthesized and characterized. It is envisioned that such actuators will eventually be utilized, variously, as molecular shuttles in biosensor devices or as nanoscale biomotors for effecting selection or separation of target microorganisms or molecules. In addition, this research is expected to enhance the fundamental understanding of molecular motors, both in vitro and in vivo and lead to modification of previously developed biomolecular machines and nanobiostructures to make them perform new functions. Some nanoscale actuators like those developed in this research may prove useful as components of micro- and nanofluidic systems. By contributing to understanding of how living cells convert chemical energy into mechanical work during actin-based and microtubule-based cell motility in cell crawling and cell mitosis, this research may lead to development of new therapeutic agents for combating invasive and metastatic cancers, gouty arthritis, Wiskott Aldrich syndrome, and those neurodegenerative disorders linked to loss of functional synapses.